BioHorizons introduces a new allogeneic growth-factor technology designed to support bone healing and tissue regeneration
What if a regenerative biomaterial could deliver growth factors in a way that more closely follows the body’s natural healing sequence?
That is the idea behind Prolifica™, a new allogeneic growth-factor technology introduced by BioHorizons.
What Exactly Is Prolifica?
Prolifica is described by BioHorizons as a naturally occurring blend of allogeneic growth factors stabilized by native human collagen.
What makes the technology particularly interesting is its preservation of what BioHorizons describes as the natural biphasic release of proteins.
Instead of delivering the growth factors through a single release phase, Prolifica is designed around two stages:
- Phase 1 — Initial release
An early surge of proteins and growth factors is intended to support initiation of the healing cascade.
- Phase 2 — Sustained release
This is followed by a prolonged release intended to provide continued regenerative support during healing.
16+ Proteins in One Regenerative Platform
According to BioHorizons, Prolifica retains a minimum of 16 unique proteins.
These proteins are associated with processes involved in cell growth, cell division, bone healing and tissue regeneration.
That is an important distinction from simply thinking about a graft material as a structural scaffold.
The concept here is to combine the regenerative potential of naturally occurring growth factors with a biomaterial platform intended to support hard-tissue healing.
Where Can Dentists Use It?
Prolifica can be used for:
- Standalone bone-grafting procedures
- Bone grafting procedures combined with autologous bone
- Bone grafting procedures combined with other allograft bone
BioHorizons’ Bigger Biomaterials Strategy
The launch raises an interesting question for regenerative dentistry:
Could the next generation of bone-grafting products be designed not only to replace lost tissue, but also to actively guide the biological events involved in regeneration?Prolifica is one example of this direction.
Its proposed biphasic growth-factor release, preservation of multiple proteins and positioning within the dental biomaterials market make it a product worth watching as more clinical experience and independent evidence become available.
References
Allogenic growth factors
BioHorizons Adds Prolifica Allogeneic Growth Factor to Biomaterials Portfolio
